Which condition is most frequently treated with antiandrogens?

Antiandrogens are primarily used in the treatment of metastatic prostate cancer. This condition is characterized by the uncontrolled growth of prostate cells, often driven by androgens, such as testosterone. Antiandrogens work by blocking the action of androgens on their receptors, which can inhibit the growth of prostate cancer cells.

In the context of metastatic prostate cancer, antiandrogens are an integral part of the therapeutic strategy, often used alongside other treatments such as androgen deprivation therapy and chemotherapy. They can help manage the disease more effectively by reducing androgenic stimulation of malignant cells.

On the other hand, while antiandrogens may be mentioned in treatments involving testicular cancer, they are not the standard or primary therapy for this condition. Testicular cancer is more commonly treated through surgical interventions (like orchiectomy) and chemotherapy, rather than relying on antiandrogen therapy.

This differentiation underscores why metastatic prostate cancer is the condition most frequently treated with antiandrogens, making this the correct choice.